Objective

At a high level, a bioreactor consists of systems in which biochemical reactions are happening at a very high rate in controlled compartments (vesicules), free of contamination from other biomolecules. Vesicular bioreactors have many and various valuable applications in drugs, cosmetic, food, agriculture and in various microfluidics devices.

The video below illustrates the capability of MOEBIUS at modeling bioreactors in order to study and optimize their properties and efficiency. Each modeled blue sphere floating in a solution is a bioreactor consisting in a phospholipid vesicle containing  protein crowders, enzymes and substrates. The vesicular encapsulation increases the enzyme-substrate recognition by several orders of magnitude, while the crowders act to stabilize the protein structures. The ensemble of vesicles and bioreactors interact dynamically in solution by means of hydrodynamic forces.

This work was performed in collaboration with Timr, S. Brandner, A. and Sterpone, F. from LBT/CNRS (Paris, France).

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