Objective

Comb-like cross-flow filter for small circulating cells and red blood cells (RBC). The device separates circulating tumor cells (CTC) when cells have a small size than RBC by leveraging hydrodynamic forces.

The objective of this study is to optimize the efficiency of a blood sorting device able to separate small white particles from red blood cells. The design parameters of the device are the blade angle, the spacing between the blades and the inlet mass flow rate.

DESIGN 1:

  • 30deg blades angles
  • 4.0 microns spacing
  • Flow rate: U0

DESIGN 3: 

  • 60 deg blades angles
  • 12.0 microns spacing
  • Flow rate: U0

DESIGN 2:

  • 60deg blades angles
  • 4.8 microns spacing
  • Flow rate: U0

DESIGN 4: 

  • 30 deg blades angles
  • 4.0 microns spacing
  • Flow rate: U0/2

 

Conclusion

The four studied configuration show a sorting efficiency ranging from less 1% to 18%. The best configuration is DESIGN 2 as shown in the figure below. Further investigations could likely improve further the efficiency.

sorting2